Intestinal microbiota in functional bowel disorders: a Rome foundation report
Identifieur interne : 000383 ( Main/Exploration ); précédent : 000382; suivant : 000384Intestinal microbiota in functional bowel disorders: a Rome foundation report
Auteurs : Magnus Simrén [Suède] ; Giovanni Barbara [Italie] ; Harry J. Flint [Royaume-Uni] ; Brennan M R. Spiegel [États-Unis] ; Robin C. Spiller [Royaume-Uni] ; Stephen Vanner [Canada] ; Elena F. Verdu [Canada] ; Peter J. Whorwell [Royaume-Uni] ; Erwin G. Zoetendal [Pays-Bas]Source :
- Gut [ 0017-5749 ] ; 2013-01.
Abstract
It is increasingly perceived that gut host–microbial interactions are important elements in the pathogenesis of functional gastrointestinal disorders (FGID). The most convincing evidence to date is the finding that functional dyspepsia and irritable bowel syndrome (IBS) may develop in predisposed individuals following a bout of infectious gastroenteritis. There has been a great deal of interest in the potential clinical and therapeutic implications of small intestinal bacterial overgrowth in IBS. However, this theory has generated much debate because the evidence is largely based on breath tests which have not been validated. The introduction of culture-independent molecular techniques provides a major advancement in our understanding of the microbial community in FGID. Results from 16S rRNA-based microbiota profiling approaches demonstrate both quantitative and qualitative changes of mucosal and faecal gut microbiota, particularly in IBS. Investigators are also starting to measure host–microbial interactions in IBS. The current working hypothesis is that abnormal microbiota activate mucosal innate immune responses which increase epithelial permeability, activate nociceptive sensory pathways and dysregulate the enteric nervous system. While we await important insights in this field, the microbiota is already a therapeutic target. Existing controlled trials of dietary manipulation, prebiotics, probiotics, synbiotics and non-absorbable antibiotics are promising, although most are limited by suboptimal design and small sample size. In this article, the authors provide a critical review of current hypotheses regarding the pathogenetic involvement of microbiota in FGID and evaluate the results of microbiota-directed interventions. The authors also provide clinical guidance on modulation of gut microbiota in IBS.
Url:
DOI: 10.1136/gutjnl-2012-302167
Affiliations:
- Canada, Italie, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Californie, Grand Manchester, Gueldre (province)
- Los Angeles, Manchester, Wageningue
- Université de Manchester, Université de Wageningue
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001B08
- to stream Istex, to step Curation: 001998
- to stream Istex, to step Checkpoint: 000039
- to stream Main, to step Merge: 000383
- to stream Main, to step Curation: 000383
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Intestinal microbiota in functional bowel disorders: a Rome foundation report</title><author><name sortKey="Simren, Magnus" sort="Simren, Magnus" uniqKey="Simren M" first="Magnus" last="Simrén">Magnus Simrén</name></author><author><name sortKey="Barbara, Giovanni" sort="Barbara, Giovanni" uniqKey="Barbara G" first="Giovanni" last="Barbara">Giovanni Barbara</name></author><author><name sortKey="Flint, Harry J" sort="Flint, Harry J" uniqKey="Flint H" first="Harry J" last="Flint">Harry J. Flint</name></author><author><name sortKey="Spiegel, Brennan M R" sort="Spiegel, Brennan M R" uniqKey="Spiegel B" first="Brennan M R" last="Spiegel">Brennan M R. Spiegel</name></author><author><name sortKey="Spiller, Robin C" sort="Spiller, Robin C" uniqKey="Spiller R" first="Robin C" last="Spiller">Robin C. Spiller</name></author><author><name sortKey="Vanner, Stephen" sort="Vanner, Stephen" uniqKey="Vanner S" first="Stephen" last="Vanner">Stephen Vanner</name></author><author><name sortKey="Verdu, Elena F" sort="Verdu, Elena F" uniqKey="Verdu E" first="Elena F" last="Verdu">Elena F. Verdu</name></author><author><name sortKey="Whorwell, Peter J" sort="Whorwell, Peter J" uniqKey="Whorwell P" first="Peter J" last="Whorwell">Peter J. Whorwell</name></author><author><name sortKey="Zoetendal, Erwin G" sort="Zoetendal, Erwin G" uniqKey="Zoetendal E" first="Erwin G" last="Zoetendal">Erwin G. Zoetendal</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AE7B2285BAA71059B504E675731C76AFE50BC3DA</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/gutjnl-2012-302167</idno><idno type="url">https://api.istex.fr/document/AE7B2285BAA71059B504E675731C76AFE50BC3DA/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B08</idno><idno type="wicri:Area/Istex/Curation">001998</idno><idno type="wicri:Area/Istex/Checkpoint">000039</idno><idno type="wicri:doubleKey">0017-5749:2013:Simren M:intestinal:microbiota:in</idno><idno type="wicri:Area/Main/Merge">000383</idno><idno type="wicri:Area/Main/Curation">000383</idno><idno type="wicri:Area/Main/Exploration">000383</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Intestinal microbiota in functional bowel disorders: a Rome foundation report</title><author><name sortKey="Simren, Magnus" sort="Simren, Magnus" uniqKey="Simren M" first="Magnus" last="Simrén">Magnus Simrén</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Suède</country></affiliation></author><author><name sortKey="Barbara, Giovanni" sort="Barbara, Giovanni" uniqKey="Barbara G" first="Giovanni" last="Barbara">Giovanni Barbara</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences and Center for Applied Biomedical Research, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Flint, Harry J" sort="Flint, Harry J" uniqKey="Flint H" first="Harry J" last="Flint">Harry J. Flint</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Microbial Ecology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen</wicri:regionArea><wicri:noRegion>Aberdeen</wicri:noRegion></affiliation></author><author><name sortKey="Spiegel, Brennan M R" sort="Spiegel, Brennan M R" uniqKey="Spiegel B" first="Brennan M R" last="Spiegel">Brennan M R. Spiegel</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>VA Greater Los Angeles Healthcare System David Geffen School of Medicine at UCLA, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Spiller, Robin C" sort="Spiller, Robin C" uniqKey="Spiller R" first="Robin C" last="Spiller">Robin C. Spiller</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, E Floor West Block, University Hospital, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Vanner, Stephen" sort="Vanner, Stephen" uniqKey="Vanner S" first="Stephen" last="Vanner">Stephen Vanner</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Verdu, Elena F" sort="Verdu, Elena F" uniqKey="Verdu E" first="Elena F" last="Verdu">Elena F. Verdu</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton</wicri:regionArea><wicri:noRegion>Hamilton</wicri:noRegion></affiliation></author><author><name sortKey="Whorwell, Peter J" sort="Whorwell, Peter J" uniqKey="Whorwell P" first="Peter J" last="Whorwell">Peter J. Whorwell</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, University of Manchester, Wythenshawe Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Zoetendal, Erwin G" sort="Zoetendal, Erwin G" uniqKey="Zoetendal E" first="Erwin G" last="Zoetendal">Erwin G. Zoetendal</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University</wicri:regionArea><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName><orgName type="university">Université de Wageningue</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Gut</title><title level="j" type="abbrev">Gut</title><idno type="ISSN">0017-5749</idno><idno type="eISSN">1468-3288</idno><imprint><publisher>BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><date type="published" when="2013-01">2013-01</date><biblScope unit="volume">62</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="159">159</biblScope></imprint><idno type="ISSN">0017-5749</idno></series><idno type="istex">AE7B2285BAA71059B504E675731C76AFE50BC3DA</idno><idno type="DOI">10.1136/gutjnl-2012-302167</idno><idno type="href">gutjnl-62-159.pdf</idno><idno type="ArticleID">gutjnl-2012-302167</idno><idno type="PMID">22730468</idno><idno type="local">gutjnl;62/1/159</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0017-5749</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">It is increasingly perceived that gut host–microbial interactions are important elements in the pathogenesis of functional gastrointestinal disorders (FGID). The most convincing evidence to date is the finding that functional dyspepsia and irritable bowel syndrome (IBS) may develop in predisposed individuals following a bout of infectious gastroenteritis. There has been a great deal of interest in the potential clinical and therapeutic implications of small intestinal bacterial overgrowth in IBS. However, this theory has generated much debate because the evidence is largely based on breath tests which have not been validated. The introduction of culture-independent molecular techniques provides a major advancement in our understanding of the microbial community in FGID. Results from 16S rRNA-based microbiota profiling approaches demonstrate both quantitative and qualitative changes of mucosal and faecal gut microbiota, particularly in IBS. Investigators are also starting to measure host–microbial interactions in IBS. The current working hypothesis is that abnormal microbiota activate mucosal innate immune responses which increase epithelial permeability, activate nociceptive sensory pathways and dysregulate the enteric nervous system. While we await important insights in this field, the microbiota is already a therapeutic target. Existing controlled trials of dietary manipulation, prebiotics, probiotics, synbiotics and non-absorbable antibiotics are promising, although most are limited by suboptimal design and small sample size. In this article, the authors provide a critical review of current hypotheses regarding the pathogenetic involvement of microbiota in FGID and evaluate the results of microbiota-directed interventions. The authors also provide clinical guidance on modulation of gut microbiota in IBS.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Grand Manchester</li><li>Gueldre (province)</li></region><settlement><li>Los Angeles</li><li>Manchester</li><li>Wageningue</li></settlement><orgName><li>Université de Manchester</li><li>Université de Wageningue</li></orgName></list><tree><country name="Suède"><noRegion><name sortKey="Simren, Magnus" sort="Simren, Magnus" uniqKey="Simren M" first="Magnus" last="Simrén">Magnus Simrén</name></noRegion><name sortKey="Simren, Magnus" sort="Simren, Magnus" uniqKey="Simren M" first="Magnus" last="Simrén">Magnus Simrén</name></country><country name="Italie"><noRegion><name sortKey="Barbara, Giovanni" sort="Barbara, Giovanni" uniqKey="Barbara G" first="Giovanni" last="Barbara">Giovanni Barbara</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Flint, Harry J" sort="Flint, Harry J" uniqKey="Flint H" first="Harry J" last="Flint">Harry J. Flint</name></noRegion><name sortKey="Spiller, Robin C" sort="Spiller, Robin C" uniqKey="Spiller R" first="Robin C" last="Spiller">Robin C. Spiller</name><name sortKey="Whorwell, Peter J" sort="Whorwell, Peter J" uniqKey="Whorwell P" first="Peter J" last="Whorwell">Peter J. Whorwell</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Spiegel, Brennan M R" sort="Spiegel, Brennan M R" uniqKey="Spiegel B" first="Brennan M R" last="Spiegel">Brennan M R. Spiegel</name></region></country><country name="Canada"><noRegion><name sortKey="Vanner, Stephen" sort="Vanner, Stephen" uniqKey="Vanner S" first="Stephen" last="Vanner">Stephen Vanner</name></noRegion><name sortKey="Verdu, Elena F" sort="Verdu, Elena F" uniqKey="Verdu E" first="Elena F" last="Verdu">Elena F. Verdu</name></country><country name="Pays-Bas"><region name="Gueldre (province)"><name sortKey="Zoetendal, Erwin G" sort="Zoetendal, Erwin G" uniqKey="Zoetendal E" first="Erwin G" last="Zoetendal">Erwin G. Zoetendal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000383 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000383 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:AE7B2285BAA71059B504E675731C76AFE50BC3DA
|texte= Intestinal microbiota in functional bowel disorders: a Rome foundation report
}}
| This area was generated with Dilib version V0.6.25. |  |